Dr James Edgar is a cell biologist and his research largely focuses on intracellular membrane traffic pathways in mammalian cells. He has specific expertise in endosomes and exosomes and uses a combination of molecular, biochemical and advanced imaging methods in his research. James has helped define the competing molecular mechanisms involved in the formation of intraluminal vesicles (exosome precursors). He also discovered that exosomes can also remain attached to the surface of donor cells, and that this retention is dependent upon the anti-viral restriction factor, tetherin.
James is currently a Sir Henry Dale Fellow based in the Department of Pathology, University of Cambridge. His lab investigate the fundamental cell biology of exosome biology in the context of antigen presentation and cancer metastasis. He is interested in bioengineering approaches and the therapeutic potential of exosomes.