Laurent Le Cam

Laurent Le Cam is the head of the « Molecular Oncogenesis » laboratory and deputy director of the Institute for Cancer Research in Montpellier (France). He graduated from Montpellier University in 1999 and then moved to Pr P. Sicinski’s laboratory at the Dana Faber Cancer Institute (Harvard Medical School, Boston, USA) where he developed genetically engineered mouse models to study the in vivo functions of several cell cycle regulators and checkpoint proteins. He started his own laboratory at Montpellier Cancer Center in 2008 where he started to study the role of the p53 pathway in metabolism. His team develops multidisciplinary research projects standing at the frontier of different fields including cancer development, inborn metabolic disorders and normal physiological responses to nutrient challenges. Recently, his laboratory uncovered unexpected roles of different key components of the p53 tumor suppressor pathway and metabolism, and showed how deregulation of these metabolic networks impinges on the epigenome and the epitanscriptome.