Pete Dedon, Singapore Professor

Pete Dedon, Singapore Professor, Massachusetts Institute of Technology

Pete Dedon is the Singapore Professor in the Department of Biological Engineering at MIT and the Lead Principal Investigator in the Singapore-MIT Alliance for Research and Technology Antimicrobial Drug Resistance IRG. With a research program that applies chemical approaches to nucleic acid biology, his group has developed a variety of analytical and informatic platforms for basic and translational research in epigenetics, epitranscriptomics, and genetic toxicology in infectious disease and cancer.

In the realm of the epitranscriptome—the dozens of modified ribonucleosides in all forms of RNA—his team has developed and applied systems-level analytics to discover a mechanism of translational regulation of gene expression in bacteria, parasites, mammalian cells, and humans. This response mechanism coordinates stress-specific reprogramming of 40-50 different tRNA modifications with alternative genetic information consisting of biased used of synonymous codons in families of stress response genes. The net result is selective translation of codon-based gene families essential for survival or phenotypic change. Pete and colleagues are leveraging these discoveries to develop new enzymatic tools for biotechnology, new methods for industrial microbiology and protein production, and novel antimicrobial agents and biological therapeutics.

Scroll to Top