Yang Shi received his PhD from NYU Medical Center and postdoctoral training with Dr. Tom Shenk at Princeton University where he discovered the transcription factor YY1. He began his independent research career at Harvard Medical School as a tenure track assistant professor in 1991 and received tenure and full professorship in the Department of Pathology at Harvard Medical School in 2004. In 2009 he joined Boston Children’s Hospital where he held a Merton Bernfield Professorship in the Department of Medicine and was also professor of Cell Biology of Harvard Medical School, where he was honored with the inaugural C. H. Waddington Professorship of Pediatrics in 2018. He joined Oxford University in 2020 and is currently Professor of Epigenetics of Oxford University and member of the Ludwig Cancer Research.
His honors include election to the American Association for the Advancement of Science (2011), The Ellison Medical Foundation Senior Scholar in Aging (2012), American Cancer Society Research Professor (2012), election to the American Academy of Arts and Sciences (2016), election to EMBO (2022), to AACR Academy (2022), the National Academy of Medicine (2022) and UK Academy of Medical Sciences (2023).